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| 1542 |
| | | Francis Xavier reaches Goa, at the start of the great mission to the east that will last the nine years until his death | |
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| 1543 |
| | | The first Europeans reach Japan by accident, blown ashore in a storm | |
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| 1550 |
| | | The Mongols, increasingly dominated by their neighbours in Manchuria, submit to them and are accepted by the Manchus as vassals | |
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| 1557 |
| | | The Portuguese establish a trading post on Macao, a small peninsula off the south coast of China | |
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| 1571 |
| | | The Spanish governor general, Legazpi, makes his capital at Manila,and names the surrounding islands the Philippines after Philip II | |
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| 1571 |
| | | The Philippines and its governor general are placed under the authority of the Spanish governor of New Spain, ruling from Mexico City | |
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| 1573 |
| | | Oda Nobunaga takes power into his own hands, after ruling for a while through the Ashikaga shogun | |
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| 1583 |
| | | The Jesuit Matteo Ricci arrives in China, and becomes the first western student of Chinese civilization | |
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| 1588 |
| | | The shogun's Tea Master awards a gold seal with the one word raku ('felicity') to a beautiful bowl, thus naming Japan's most famous ware | |
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| c. 1595 |
| | | The writings of Matteo Ricci introduce Kung Fu Tzu to Europe under a Latin version of his name - Confucius | |
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